Interleukin-11 protects against renal ischemia and reperfusion injury
نویسندگان
چکیده
منابع مشابه
Interleukin-11 protects against renal ischemia and reperfusion injury.
Renal ischemia reperfusion (IR) injury causes renal tubular necrosis, apoptosis, and inflammation leading to acute and chronic kidney dysfunction. IL-11 is a multifunctional hematopoietic cytokine clinically approved to treat chemotherapy-induced thrombocytopenia. Recent studies suggest that IL-11 also has potent antiapoptotic and antinecrotic properties. In this study, we tested the hypothesis...
متن کاملRelaxin protects against renal ischemia-reperfusion injury.
Relaxin, a pregnancy hormone, has antiapoptotic and anti-inflammatory properties. The aim of this study was to determine the effects of relaxin on ischemia-reperfusion (IR)-induced acute kidney injury. Male rats underwent unilateral nephrectomy and contralateral renal IR (45 min of renal pedicle clamping). Rats were divided into three groups: 1) sham group, 2) IR group, and 3) IR-RLX group (rat...
متن کاملCorrection: Prion Protein Protects against Renal Ischemia/Reperfusion Injury
There are errors in the author affiliations for Fan Zhang. The affiliations should appear as shown here: Fan Zhang 13, 15 2 Department of Pathology, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio, United States of America, 13 Department of Neurosurgery, Shandong University, Shandong provincial hospital, Jinan, The People’s Republic of China, 15 Departm...
متن کاملLuteolin Treatment Protects against Renal Ischemia-Reperfusion Injury in Rats
Renal ischemia-reperfusion (I/R) injury is a common but severe scientific problem. Luteolin has great anti-inflammatory and antioxidant effects. In this study, we studied the effect of luteolin on renal I/R injury in rats. Intragastric administration of luteolin or saline was performed in Sprague-Dawley rats before (40 mg/kg for three days) and after (one day) renal I/R modeling. Kidney and blo...
متن کاملPrion Protein Protects against Renal Ischemia/Reperfusion Injury
The cellular prion protein (PrPC), a protein most noted for its link to prion diseases, has been found to play a protective role in ischemic brain injury. To investigate the role of PrPC in the kidney, an organ highly prone to ischemia/reperfusion (IR) injury, we examined wild-type (WT) and PrPC knockout (KO) mice that were subjected to 30-min of renal ischemia followed by 1, 2, or 3 days of re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2012
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00220.2012